The sHsps are involved in stress response mechanisms and survival strategies that regulate cell death processes
When under oxidative stress (OS) conditions, Hb is oxidized, it binds to the cytoplasmic domain of membrane protein band 3, triggering the formation of aggregates and the covalent linkage of natural anti-band 3 antibodies that may lead to premature RBC removal by splenic macrophages [1, 9]
Yoo M-H, Gu X, Xu X-M, Kim J-Y, Carlson BA, Patterson AD et al (2010) Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimers disease
doi: 10.1016/j.kint.2025.07.023 26 ParkJJooYSNamBYKimGParkJTYooTHet al
HerbalGram: American Botanical Council
Iyengar et al., in their study on the impact of ribociclib on serous ovarian cancer cells, demonstrated that ribociclib can induce a pseudo-senescent state in these cancer cells [88]